Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity
Locus coeruleus (LC) is implicated in anxiety and depression (Itoi and Sugimoto, 2010), and is often the first place where Alzheimer’s disease (AD)-related pathology appears (Mather and Harley, 2016). Noradrenaline (NA) is known to inhibit amyloid-induced …